I'm dealing with a brain stimulation.

My EEG contains large spikes (>3 mV) when stimulation occurs. I want to remove the 50 Hz noise, but I can't use notch filter because it creates large artifacts.

Do you think that Kalman Filter could remove the 50 Hz noise?

Thanks for your comments. This is my registration

If i apply a notch filter i will have ringing artifacts due to the large spikes.If so I can't use the signal anymore. So my point is : i have to remove the 50hz component without using a notch filter.( I cannot delete the spikes with interpolation) My idea is to estimate the signal rappresenting the 50 hz component with the kalman filter and then subtracting from the original signal